Resolving Diagnostic Deadlocks in Systemic Inflammatory Autoimmune Diseases (SAID)
Short Summary
Systemic autoinflammatory diseases (SAIDs) are rare, highly dynamic, and heterogeneous conditions of short, violent episodes of immune over-activation. This project aims to develop a novel analytic approach to overcome the diagnostic challenges in SAIDs. By doing so, we aim to not only accelerate the diagnosis but also to allow for personalized patient interventions.
Goals
This project aims to develop a novel approach to accelerate the diagnosis, to shed light into the underlying pathways and to personalize patient interventions.
Significance
An accelerated, timely, and correct diagnosis is crucial to avoid unnecessary invasive investigations and inadequate treatment decisions in SAID patients, benefiting clinicians, patients, and society.
Background
SAIDs are characterized by long dormant periods with no or only minor clinical symptoms, interrupted by short flashes of inflammation. These flashes can lead to lasting tissue damage and loss of function. However, despite considerable scientific advances, the diagnosis of around 70% of SAIDs remains exceptionally challenging because of the absence of objective diagnostic criteria. Therefore, the diagnosis is usually only established with significant delay.
iDoc
Prof. Dr. Klaus Eyer
Institute of Pharmaceutical Sciences, ETH Zurich
Co-Investigators
- Dr. Irina Giurgea, Hôpital Trousseau
Consortium
- Hôpital Trousseau
Status
In Progress
- 5th Call, iDoc
Funded by
