The primary objective of this application is to generate a foundation for the development of personalized strategies to activate energy burning brown adipose tissue to improve metabolism. This goal will be achieved through leveraging existing cohorts of patients and volunteers, which will drive the development of three Swiss Platforms for the advancement of Personalized Medicine. Building on this infrastructure, the consortium will develop technologies, which allow the individual assessment of patients. Ultimately. we will utilize the use the generated data on human energy burning brown adipose tissue, to understand the differences between individuals and identify new strategies to induce energy burning and thus treat obesity.