Non-invasive, 3D histopathological imaging has the prospect to simplify classical clinical histopathology workflows, render whole block biopsy analysis efficient and it ensures that samples can be subjected to further molecular analyses. Careful analysis of the tissue morphology and molecular characteristics of a biopsy provide the basis for patient stratification and further clinical management. In this project, thyroid carcinomas (TCs) are examined as a showcase for the implementation of such holistic tissue analyses approach for precision medicine.