In 2021, the Swiss Personalized Health Network (SPHN) and the Personalized Health and Related Technologies (PHRT) initiative from the ETH Domain jointly launched the call for “National Data Streams” (NDS). After a two-step evaluation procedure, 4 NDS projects have been selected for funding in the fields of infectious diseases in intensive care medicine, oncology, pediatrics, and health services research. Each NDS project comprises a Switzerland-wide multidisciplinary consortium that invests in the development of a sustainable data infrastructure for high-end data-driven and personalized health research.